3-hydroxyhexanoylcarnitine (1) to cis-3,4-methyleneheptanoylglycine

Numerator Metabolite

Structure of 3-hydroxyhexanoylcarnitine (1)
Metabolite Accession: GCST90200228
Name: 3-hydroxyhexanoylcarnitine (1)
Hmdb Id: HMDB0013131
Super Pathway: NA
Sub Pathway: NA
Inchikey: VYEONLJQPYRKAN

Denominator Metabolite

Metabolite Accession: GCST90200274
Name: cis-3,4-methyleneheptanoylglycine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs67757078

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.208
Position:
76169456
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
10.346
Reference Allele:
G
-log10(P):
-56.088
MAF:
0.335
Beta (Num):
0.124
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.084
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB SLC44A5 MSH4 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, specifically mitochondrial beta-oxidation.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, acyl glycine metabolism.5[1], 6[2], 7[3]

Ratio Explanation:

The ratio of 3-hydroxyhexanoylcarnitine to cis-3,4-methyleneheptanoylglycine may reflect alterations in fatty acid oxidation, potentially influenced by ACADM activity, though a direct relationship is not established.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype information is available to establish a link.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data