glutamine conjugate of c6h10o2 (2)* to n-acetylglycine

Numerator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of n-acetylglycine
Metabolite Accession: GCST90199688
Name: n-acetylglycine
Hmdb Id: HMDB0000532
Super Pathway: NA
Sub Pathway: NA
Inchikey: OKJIRPAQVSHGFK

Associated Genomic Regions

Region: rs35630725;rs1890452

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.206
Position:
76192508
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
10.167
Reference Allele:
G
-log10(P):
-54.235
MAF:
0.337
Beta (Num):
0.129
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.077
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, amino acid conjugation.4[1], 5[2]

Denominator Metabolite Explanation:

Amino acid metabolism, detoxification.6[1], 7[2]

Ratio Explanation:

The ratio may reflect a metabolic shift in detoxifying accumulated medium-chain fatty acids, favoring glutamine conjugation when ACADM function is impaired.3[1], 4[2], 5[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype was provided; therefore, a causal link connecting ACADM, the metabolite ratio, and a specific phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data