n-acetylglycine to glycine

Numerator Metabolite

Structure of n-acetylglycine
Metabolite Accession: GCST90199688
Name: n-acetylglycine
Hmdb Id: HMDB0000532
Super Pathway: NA
Sub Pathway: NA
Inchikey: OKJIRPAQVSHGFK

Denominator Metabolite

Structure of glycine
Metabolite Accession: GCST90200707
Name: glycine
Hmdb Id: HMDB0000123
Super Pathway: NA
Sub Pathway: NA
Inchikey: DHMQDGOQFOQNFH

Associated Genomic Regions

Region: rs2788654

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.163
Position:
76219569
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
-9.278
Reference Allele:
C
-log10(P):
-45.509
MAF:
0.338
Beta (Num):
-0.076
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.087
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Amino acid metabolism, fatty acid metabolism.4[1]

Denominator Metabolite Explanation:

Amino acid metabolism, one-carbon metabolism.5[1], 6[2]

Ratio Explanation:

N-acetylglycine is formed from glycine and acetyl-CoA.7[1] ACADM is involved in fatty acid metabolism, which produces acetyl-CoA, but does not directly metabolize either molecule.1[2], 8[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype is associated with this ratio, but the ACADM gene is linked to Medium-chain acyl-CoA dehydrogenase deficiency (MCADD), a disorder of fatty acid oxidation.1[1], 9[2]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data