branched-chain, straight-chain, or cyclopropyl 10:1 fatty acid (1)* to glutamine conjugate of c7h12o2*

Numerator Metabolite

Metabolite Accession: GCST90200251
Name: branched-chain, straight-chain, or cyclopropyl 10:1 fatty acid (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200167
Name: glutamine conjugate of c7h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs1146581

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.175
Position:
76213024
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
-9.530
Reference Allele:
T
-log10(P):
-47.903
MAF:
0.337
Beta (Num):
-0.067
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.109
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Xenobiotic detoxification, Amino acid conjugation

Ratio Explanation:

The ratio likely reflects ACADM enzyme efficiency; reduced function may increase the C10:1 fatty acid numerator while byproducts are cleared via glutamine conjugation (denominator).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced ACADM function, indicated by the ratio, suggests impaired fatty acid oxidation. No associated phenotype was provided to complete the causal link.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data