glutamine conjugate of c6h10o2 (1)* to 3-hydroxydecanoate

Numerator Metabolite

Metabolite Accession: GCST90200176
Name: glutamine conjugate of c6h10o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxydecanoate
Metabolite Accession: GCST90199693
Name: 3-hydroxydecanoate
Hmdb Id: HMDB0002203
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYSSBMZUBSBFJL

Associated Genomic Regions

Region: rs35630725;rs1890452

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.178
Position:
76192508
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
10.451
Reference Allele:
G
-log10(P):
-57.196
MAF:
0.339
Beta (Num):
0.140
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.038
SE (Den):
0.016
No CNV overlap
rQTL cluster:
161
Reaction Distance:
NA
Closest Genes:
ACADM RABGGTB MSH4 SLC44A5 ASB17

Region: rs6701374

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.254
Position:
151903858
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
14.264
Reference Allele:
A
-log10(P):
-104.615
MAF:
0.292
Beta (Num):
0.043
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.211
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic detoxification

Denominator Metabolite Explanation:

Fatty acid beta-oxidation

Ratio Explanation:

An elevated ratio suggests a disruption in fatty acid metabolism, where the clearance of a xenobiotic conjugate is favored over beta-oxidation of fatty acids.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The ACADM gene, involved in fatty acid beta-oxidation, is linked to diverticular disease.4[1], 5[2] An altered ratio of a glutamine conjugate to a fatty acid intermediate could reflect metabolic shifts associated with this condition, although a direct causal link is not established.

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data