branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to docosadienoate (22:2n6)

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of docosadienoate (22:2n6)
Metabolite Accession: GCST90199711
Name: docosadienoate (22:2n6)
Hmdb Id: HMDB0061714
Super Pathway: NA
Sub Pathway: NA
Inchikey: HVGRZDASOHMCSK

Associated Genomic Regions

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
14
Beta (Ratio):
-0.513
Position:
74040136
SE (Ratio):
0.036
Effect Allele:
A
Z-score (Ratio):
-14.342
Reference Allele:
G
-log10(P):
-105.737
MAF:
0.029
Beta (Num):
-0.480
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.033
SE (Den):
0.045
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis and beta-oxidation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.7[1], 8[2]

Ratio Explanation:

The ratio may reflect ACOT-mediated hydrolysis of 12:1-CoA, increasing the numerator, relative to the docosadienoate pool, indicating altered fatty acid metabolism.1[1], 2[2], 9[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided; therefore, a causal link between the ACOT gene, the fatty acid ratio, and a specific phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data