arachidonate (20:4n6) to dodecadienoate (12:2)*

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174564

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.315
Position:
61588305
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
-21.411
Reference Allele:
A
-log10(P):
-232.501
MAF:
0.344
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
4.39e-05
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.641
Position:
74040136
SE (Ratio):
0.041
Effect Allele:
A
Z-score (Ratio):
15.537
Reference Allele:
G
-log10(P):
-123.668
MAF:
0.030
Beta (Num):
0.036
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
-0.605
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Unsaturated fatty acid biosynthesis

Denominator Metabolite Explanation:

Fatty Acid Dicarboxylate Metabolism7[1]

Ratio Explanation:

The ratio of arachidonate to dodecadienoate may reflect the balance between polyunsaturated fatty acid synthesis by FADS enzymes and fatty acid degradation involving ACOT enzymes.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 regulate arachidonic acid synthesis, impacting inflammatory pathways and lipid levels.8[1], 6[2], 9[3] This altered inflammatory state and dyslipidemia are linked to an increased risk for pure hypercholesterolemia and benign colorectal neoplasms.8[4], 4[5], 10[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data