branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to linolenate [alpha or gamma; (18:3n3 or 6)]

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of linolenate [alpha or gamma; (18:3n3 or 6)]
Metabolite Accession: GCST90199748
Name: linolenate [alpha or gamma; (18:3n3 or 6)]
Hmdb Id: HMDB0003073,HMDB0001388
Super Pathway: NA
Sub Pathway: NA
Inchikey: DTOSIQBPPRVQHS

Associated Genomic Regions

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.530
Position:
74040136
SE (Ratio):
0.035
Effect Allele:
A
Z-score (Ratio):
-15.298
Reference Allele:
G
-log10(P):
-119.969
MAF:
0.029
Beta (Num):
-0.480
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.050
SE (Den):
0.043
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, Fatty acid beta-oxidation.7[1], 8[2], 9[3], 10[4]

Denominator Metabolite Explanation:

alpha-Linolenic acid metabolism, Linoleic acid metabolism.11[1], 12[2], 13[3], 14[4]

Ratio Explanation:

Altered ACOT enzyme function could shift substrate preference between the acyl-CoA precursors of a C12:1 fatty acid and linolenate, thereby changing their ratio.15[1], 2[2], 16[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype is provided; therefore, a causal link between the genetic factors, the metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data