cis-4-decenoylcarnitine (c10:1) to dodecadienoate (12:2)*

Numerator Metabolite

Structure of cis-4-decenoylcarnitine (c10:1)
Metabolite Accession: GCST90199880
Name: cis-4-decenoylcarnitine (c10:1)
Hmdb Id: HMDB0013205
Super Pathway: NA
Sub Pathway: NA
Inchikey: GOOOCIIXFLVRAG

Denominator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs7523082

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.158
Position:
151848126
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
11.209
Reference Allele:
T
-log10(P):
-65.475
MAF:
0.396
Beta (Num):
0.039
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.119
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC LINGO4

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.640
Position:
74040136
SE (Ratio):
0.040
Effect Allele:
A
Z-score (Ratio):
15.849
Reference Allele:
G
-log10(P):
-128.581
MAF:
0.030
Beta (Num):
0.035
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
-0.605
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

Region: rs620484

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.133
Position:
4114211
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-8.902
Reference Allele:
G
-log10(P):
-42.044
MAF:
0.314
Beta (Num):
-0.045
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.088
SE (Den):
0.016
No CNV overlap
rQTL cluster:
113
Reaction Distance:
NA
Closest Genes:
C6orf201 ECI2 FAM217A PRPF4B C6ORF50

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation

Ratio Explanation:

The ratio of cis-4-decenoylcarnitine to dodecadienoate may reflect alterations in the efficiency of mitochondrial fatty acid beta-oxidation, potentially influenced by ACADM or ECI2 activity.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data