(2 or 3)-decenoate (10:1n7 or n8) to docosapentaenoate n3 DPA; 22:5n3

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Associated Genomic Regions

Region: rs174580

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.145
Position:
61606642
SE (Ratio):
0.013
Effect Allele:
G
Z-score (Ratio):
11.324
Reference Allele:
A
-log10(P):
-66.780
MAF:
0.350
Beta (Num):
0.008
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.137
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FADS3 FEN1 TMEM258

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.378
Position:
74040136
SE (Ratio):
0.036
Effect Allele:
A
Z-score (Ratio):
-10.490
Reference Allele:
G
-log10(P):
-57.607
MAF:
0.029
Beta (Num):
-0.345
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.032
SE (Den):
0.043
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

Region: rs689308

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.152
Position:
4127730
SE (Ratio):
0.013
Effect Allele:
C
Z-score (Ratio):
11.521
Reference Allele:
A
-log10(P):
-69.038
MAF:
0.316
Beta (Num):
0.158
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.006
SE (Den):
0.016
No CNV overlap
rQTL cluster:
113
Reaction Distance:
NA
Closest Genes:
ECI2 C6orf201 FAM217A PRPF4B C6ORF50

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.6[1]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis and beta-oxidation.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio compares a medium-chain fatty acid oxidation intermediate to a long-chain omega-3 fatty acid, potentially reflecting the efficiency of beta-oxidation catalyzed by ECI2.3[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered ECI2 or FADS gene function disrupts fatty acid oxidation and synthesis, reflected by the ratio. This dysregulation of lipid pools is a known risk factor for developing metabolic phenotypes like hypercholesterolemia, type 2 diabetes, and cholelithiasis (gallstones).10[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:ECI2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data