branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to linoleate (18:2n6)

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Associated Genomic Regions

Region: rs147794363

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.396
Position:
73271372
SE (Ratio):
0.050
Effect Allele:
T
Z-score (Ratio):
-7.876
Reference Allele:
C
-log10(P):
-33.322
MAF:
0.011
Beta (Num):
-0.246
Novel Locus:
Yes ✔️
SE (Num):
0.069
Beta (Den):
0.150
SE (Den):
0.070
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
DPF3 DCAF4 ZFYVE1 RGS6 RBM25

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.512
Position:
74040136
SE (Ratio):
0.032
Effect Allele:
A
Z-score (Ratio):
-16.226
Reference Allele:
G
-log10(P):
-134.663
MAF:
0.029
Beta (Num):
-0.480
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.032
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.4[1]

Denominator Metabolite Explanation:

Linoleic acid metabolism.5[1]

Ratio Explanation:

The ratio reflects the balance between a C12:1 fatty acid and linoleate, potentially influenced by the substrate specificity of ACOT enzymes regulating their free pools.6[1], 7[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No associated phenotype was provided; therefore, a causal link between genetic factors (ACOT), the fatty acid ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data