3-hydroxydecanoylcarnitine to dodecadienoate (12:2)*

Numerator Metabolite

Structure of 3-hydroxydecanoylcarnitine
Metabolite Accession: GCST90200246
Name: 3-hydroxydecanoylcarnitine
Hmdb Id: HMDB0061636
Super Pathway: NA
Sub Pathway: NA
Inchikey: VCRSQDIROUELAR

Denominator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs2932586

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.135
Position:
151922808
SE (Ratio):
0.014
Effect Allele:
C
Z-score (Ratio):
9.995
Reference Allele:
T
-log10(P):
-52.489
MAF:
0.400
Beta (Num):
0.022
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.113
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
S100A10 THEM4 S100A11 THEM5 C2CD4D

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.663
Position:
74040136
SE (Ratio):
0.039
Effect Allele:
A
Z-score (Ratio):
17.078
Reference Allele:
G
-log10(P):
-148.889
MAF:
0.030
Beta (Num):
0.058
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
-0.605
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.6[1], 7[2]

Ratio Explanation:

An elevated ratio may indicate altered mitochondrial fatty acid oxidation, where the conversion of 3-hydroxydecanoylcarnitine is impaired, potentially influenced by ACOT2 activity on acyl-CoAs.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data