(2 or 3)-decenoate (10:1n7 or n8) to palmitate (16:0)

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs148925835

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.466
Position:
73282698
SE (Ratio):
0.061
Effect Allele:
G
Z-score (Ratio):
-7.697
Reference Allele:
T
-log10(P):
-31.904
MAF:
0.010
Beta (Num):
-0.355
Novel Locus:
Yes ✔️
SE (Num):
0.074
Beta (Den):
0.111
SE (Den):
0.074
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
DPF3 DCAF4 ZFYVE1 RBM25 RGS6

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.403
Position:
74040136
SE (Ratio):
0.036
Effect Allele:
A
Z-score (Ratio):
-11.094
Reference Allele:
G
-log10(P):
-64.184
MAF:
0.029
Beta (Num):
-0.345
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.058
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.3[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis and beta-oxidation.4[1], 5[2]

Ratio Explanation:

The ratio may reflect the balance between medium-chain fatty acid metabolism, influenced by ACOT2 which can act on decanoyl-CoA, and palmitate synthesis/breakdown.1[1], 6[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No definitive ratio-phenotype link can be established as no associated phenotype is provided.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data