branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 3-hydroxybutyrate

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxybutyrate (bhba)
Metabolite Accession: GCST90200367
Name: 3-hydroxybutyrate (bhba)
Hmdb Id: HMDB0000011
Super Pathway: NA
Sub Pathway: NA
Inchikey: WHBMMWSBFZVSSR

Associated Genomic Regions

Region: rs113860908

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.433
Position:
74070803
SE (Ratio):
0.030
Effect Allele:
G
Z-score (Ratio):
-14.340
Reference Allele:
A
-log10(P):
-105.715
MAF:
0.041
Beta (Num):
-0.358
Novel Locus:
No
SE (Num):
0.037
Beta (Den):
0.076
SE (Den):
0.038
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT6 ACOT4 ACOT2 DNAL1 HEATR4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Ketone body metabolism

Ratio Explanation:

An elevated ratio may indicate increased ACOT2 activity, leading to hydrolysis of 12:1 fatty acyl-CoA, which reduces its entry into beta-oxidation and subsequent ketogenesis.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype was provided; therefore, a causal link cannot be established between the genetic factors, the metabolic ratio, and a phenotype.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data