(2 or 3)-decenoate (10:1n7 or n8) to oleate/vaccenate (18:1)

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Associated Genomic Regions

Region: rs148925835

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.454
Position:
73282698
SE (Ratio):
0.059
Effect Allele:
G
Z-score (Ratio):
-7.704
Reference Allele:
T
-log10(P):
-31.957
MAF:
0.010
Beta (Num):
-0.355
Novel Locus:
Yes ✔️
SE (Num):
0.074
Beta (Den):
0.099
SE (Den):
0.073
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
DPF3 DCAF4 ZFYVE1 RBM25 RGS6

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.381
Position:
74040136
SE (Ratio):
0.035
Effect Allele:
A
Z-score (Ratio):
-10.769
Reference Allele:
G
-log10(P):
-60.593
MAF:
0.029
Beta (Num):
-0.345
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.035
SE (Den):
0.044
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.3[1], 4[2], 5[3], 6[4]

Denominator Metabolite Explanation:

Fatty acid biosynthesis and metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio may reflect ACOT2's hydrolytic activity, comparing medium-chain (C10) against long-chain (C18) acyl-CoA pools, thereby influencing their metabolic fates.3[1], 10[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype data is available; however, genetic variation in ACOT2 likely alters mitochondrial fatty acid metabolism by modulating acyl-CoA levels.1[1], 11[2]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data