dodecadienoate (12:2)* to linolenate [alpha or gamma; (18:3n3 or 6)]

Numerator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of linolenate [alpha or gamma; (18:3n3 or 6)]
Metabolite Accession: GCST90199748
Name: linolenate [alpha or gamma; (18:3n3 or 6)]
Hmdb Id: HMDB0003073,HMDB0001388
Super Pathway: NA
Sub Pathway: NA
Inchikey: DTOSIQBPPRVQHS

Associated Genomic Regions

Region: rs2338209

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.137
Position:
151903823
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
-11.397
Reference Allele:
G
-log10(P):
-67.610
MAF:
0.361
Beta (Num):
-0.113
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.023
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

Region: rs148925835

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.439
Position:
73282698
SE (Ratio):
0.056
Effect Allele:
G
Z-score (Ratio):
-7.771
Reference Allele:
T
-log10(P):
-32.483
MAF:
0.010
Beta (Num):
-0.379
Novel Locus:
Yes ✔️
SE (Num):
0.073
Beta (Den):
0.060
SE (Den):
0.072
No CNV overlap
rQTL cluster:
45
Reaction Distance:
NA
Closest Genes:
DPF3 DCAF4 ZFYVE1 RBM25 RGS6

Region: rs151154986

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.655
Position:
74040136
SE (Ratio):
0.034
Effect Allele:
A
Z-score (Ratio):
-19.391
Reference Allele:
G
-log10(P):
-191.197
MAF:
0.030
Beta (Num):
-0.605
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.050
SE (Den):
0.043
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid, Dicarboxylate metabolism.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Linoleic and Linolenic acid metabolism.6[1], 7[2]

Ratio Explanation:

A higher ratio may indicate increased ACOT2 activity, which preferentially hydrolyzes C14-C20 acyl-CoAs, potentially altering the balance between different classes of fatty acids.8[1]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype association was provided in the input data, so no causal link between the ACOT2 gene, the metabolite ratio, and a phenotype can be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data