(2 or 3)-decenoate (10:1n7 or n8) to glycerol

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of glycerol
Metabolite Accession: GCST90200325
Name: glycerol
Hmdb Id: HMDB0000131
Super Pathway: NA
Sub Pathway: NA
Inchikey: PEDCQBHIVMGVHV

Associated Genomic Regions

Region: rs151154986

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.404
Position:
74040136
SE (Ratio):
0.042
Effect Allele:
A
Z-score (Ratio):
-9.711
Reference Allele:
G
-log10(P):
-49.659
MAF:
0.029
Beta (Num):
-0.345
Novel Locus:
No
SE (Num):
0.044
Beta (Den):
0.059
SE (Den):
0.039
No CNV overlap
rQTL cluster:
44
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT4 ACOT1 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, Fatty acid metabolism.3[1]

Denominator Metabolite Explanation:

Glycerolipid metabolism, Glycolysis, Gluconeogenesis.4[1], 5[2]

Ratio Explanation:

ACOT2 hydrolyzes decenoyl-CoA (numerator precursor), affecting fatty acid levels, while glycerol (denominator) is the backbone of triglycerides, reflecting overall lipid turnover.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype is provided, therefore no causal link between ACOT2, the metabolite ratio, and a phenotype can be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data