docosapentaenoate (n6 dpa; 22:5n6) to palmitoylcarnitine (c16)

Numerator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Denominator Metabolite

Structure of palmitoylcarnitine (c16)
Metabolite Accession: GCST90199666
Name: palmitoylcarnitine (c16)
Hmdb Id: HMDB0000222
Super Pathway: NA
Sub Pathway: NA
Inchikey: XOMRRQXKHMYMOC

Associated Genomic Regions

Region: rs388891

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.183
Position:
131700794
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-10.114
Reference Allele:
G
-log10(P):
-53.698
MAF:
0.294
Beta (Num):
-0.058
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.125
SE (Den):
0.017
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid elongation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation

Ratio Explanation:

The ratio may reflect altered carnitine-dependent fatty acid transport, where reduced SLC22A5 function could impair palmitoylcarnitine formation and affect long-chain fatty acid metabolism.1[1], 4[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5-mediated carnitine uptake may alter fatty acid metabolism, influencing hematological parameters like monocyte and platelet counts, potentially through effects on cell membrane composition or inflammatory signaling.

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data