myristoleoylcarnitine (c14:1)* to glutamine conjugate of c7h12o2*

Numerator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Denominator Metabolite

Metabolite Accession: GCST90200167
Name: glutamine conjugate of c7h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs4705857

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.134
Position:
131737030
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
8.413
Reference Allele:
C
-log10(P):
-37.758
MAF:
0.313
Beta (Num):
0.076
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.058
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 IRF1 P4HA2

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, carnitine shuttle.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Xenobiotic metabolism, glutamine metabolism.7[1], 8[2]

Ratio Explanation:

The ratio may reflect the transport activity of SLC22A5, balancing carnitine-dependent fatty acid metabolism against the clearance of other organic cation-like molecules.1[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A5/IRF1 function likely impacts carnitine levels and immune regulation, influencing inflammatory responses and subsequently affecting circulating monocyte and white blood cell counts, which are linked to various inflammatory conditions.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data