glutamine conjugate of c7h12o2* to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Metabolite Accession: GCST90200167
Name: glutamine conjugate of c7h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs4705857

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.148
Position:
131737030
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-9.416
Reference Allele:
C
-log10(P):
-46.807
MAF:
0.313
Beta (Num):
-0.058
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.090
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 IRF1 P4HA2

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic Metabolism / Amino Acid Conjugation.4[1]

Denominator Metabolite Explanation:

Fatty Acid Oxidation / Carnitine Shuttle.5[1], 6[2]

Ratio Explanation:

This ratio likely reflects the activity of the SLC22A5 transporter, which directly influences levels of palmitoleoylcarnitine for fatty acid oxidation.7[1], 8[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in SLC22A5 alters carnitine-dependent fatty acid transport, impacting cellular energy metabolism.8[1], 9[2] This dysregulation likely affects the function and proliferation of immune cells like monocytes and neutrophils, leading to changes in their circulating counts.10[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data