palmitoleoylcarnitine (c16:1)* to 10-nonadecenoate (19:1n9)

Numerator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Denominator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Associated Genomic Regions

Region: rs635619

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.125
Position:
131720265
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
9.589
Reference Allele:
G
-log10(P):
-48.472
MAF:
0.294
Beta (Num):
0.092
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.034
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation; carnitine shuttle.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Long-chain fatty acid metabolism.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio likely reflects the efficiency of carnitine-dependent fatty acid transport by SLC22A5, impacting the balance between cellular acylcarnitines and free fatty acids.1[1], 7[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in SLC22A5 may alter carnitine transport, disrupting fatty acid metabolism and cellular energy. This could plausibly affect the proliferation and function of energy-dependent hematopoietic cells, leading to altered blood cell counts.11[1], 12[2], 13[3]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data