arachidonate (20:4n6) to 3-hydroxyoleoylcarnitine

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Associated Genomic Regions

Region: rs10076701

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.176
Position:
131596419
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
-10.564
Reference Allele:
C
-log10(P):
-58.395
MAF:
0.445
Beta (Num):
-0.057
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.119
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
PDLIM4 P4HA2 SLC22A4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Eicosanoid synthesis, Inflammation4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation7[1]

Ratio Explanation:

The ratio likely reflects altered fatty acid metabolism and inflammatory status, potentially influenced by the transport activity of SLC22A4/A5 affecting carnitine availability.8[1], 9[2], 10[3], 11[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SLC22A4/A5 are associated with altered transport of carnitine and other organic cations, influencing fatty acid oxidation and inflammatory pathways.8[1], 9[2], 1[3], 11[4], 2[5] This dysfunction, combined with altered arachidonate metabolism, contributes to an inflammatory state seen in gout and affects various blood cell counts.12[6], 13[7], 14[8]

Phenotype Driver:

Gene-centric:SLC22A4/SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data