dodecadienoate (12:2)* to oleoylcarnitine (c18:1)

Numerator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs7542137

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.157
Position:
151868892
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
-10.131
Reference Allele:
T
-log10(P):
-53.870
MAF:
0.398
Beta (Num):
-0.118
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.039
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs388891

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.168
Position:
131700794
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
-10.156
Reference Allele:
G
-log10(P):
-54.128
MAF:
0.294
Beta (Num):
-0.038
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.130
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.4[1], 5[2], 6[3], 7[4], 8[5]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.9[1], 10[2], 11[3]

Ratio Explanation:

Increased ratio may suggest impaired carnitine-dependent fatty acid import or altered mitochondrial fatty acid metabolism, as SLC22A5 transports oleoylcarnitine's precursor (carnitine).1[1], 2[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can impair carnitine uptake, affecting fatty acid oxidation in hematopoietic stem cells. This may alter the differentiation and proliferation of blood cell lineages, leading to changes in monocyte, platelet, and other blood cell counts.1[1], 12[2], 13[3], 14[4], 15[5], 16[6]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data