(2 or 3)-decenoate (10:1n7 or n8) to acetylcarnitine (c2)

Numerator Metabolite

Metabolite Accession: GCST90200263
Name: (2 or 3)-decenoate (10:1n7 or n8)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Associated Genomic Regions

Region: rs272849

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.138
Position:
131690241
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-9.311
Reference Allele:
G
-log10(P):
-45.816
MAF:
0.374
Beta (Num):
-0.026
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.112
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/oxidation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Carnitine shuttle, fatty acid metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects altered carnitine homeostasis and fatty acid metabolism, likely due to impaired function of the carnitine transporter SLC22A5.1[1], 10[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered SLC22A5 function impacts carnitine-dependent fatty acid oxidation, a key energy source for hematopoietic cells. This dysfunction likely leads to the observed hematological phenotypes (altered monocyte, platelet, WBC counts) and changes in related metabolic markers like uric acid.11[1], 12[2], 10[3], 13[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data