3-hydroxyoleoylcarnitine to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs10076701

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.165
Position:
131596419
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
9.683
Reference Allele:
C
-log10(P):
-49.382
MAF:
0.446
Beta (Num):
0.119
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.046
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
PDLIM4 P4HA2 SLC22A4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.5[1], 6[2]

Denominator Metabolite Explanation:

Long-chain fatty acid biosynthesis.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects the balance between fatty acid oxidation, for which carnitine transport is crucial, and long-chain fatty acid synthesis.10[1], 5[2], 9[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A4/A5 function may impair carnitine-dependent fatty acid transport, altering acylcarnitine levels.11[1], 12[2], 10[3] This dysregulation, potentially alongside altered ergothioneine transport, contributes to inflammation and altered uric acid handling, which are associated with gout and the observed hematological and biochemical changes.1[4], 13[5], 14[6], 15[7]

Phenotype Driver:

Gene-centric:SLC22A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data