arachidonate (20:4n6) to myristoylcarnitine (c14)

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of myristoylcarnitine (c14)
Metabolite Accession: GCST90199730
Name: myristoylcarnitine (c14)
Hmdb Id: HMDB000506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PSHXNVGSVNEJBD

Associated Genomic Regions

Region: rs272880

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.181
Position:
131670178
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-9.984
Reference Allele:
T
-log10(P):
-52.375
MAF:
0.294
Beta (Num):
-0.065
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.116
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 P4HA2 PDLIM4 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Arachidonic acid metabolism, Eicosanoid synthesis.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Fatty acid oxidation, Carnitine shuttle.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio may reflect a balance between pro-inflammatory arachidonate signaling and carnitine-dependent fatty acid oxidation.3[1], 9[2], 6[3] Altered SLC22A5 function can decrease myristoylcarnitine, increasing the ratio.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in `SLC22A5` can impair carnitine transport, affecting fatty acid metabolism in hematopoietic and immune cells.10[1], 11[2], 12[3] This dysregulation, potentially alongside inflammatory signals from arachidonate pathways, may alter the production and counts of neutrophils, platelets, and other blood cells.13[4], 14[5]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data