histidine betaine (hercynine)* to lignoceroylcarnitine (c24)*

Numerator Metabolite

Structure of histidine betaine (hercynine)*
Metabolite Accession: GCST90199927
Name: histidine betaine (hercynine)*
Hmdb Id: HMDB0029422
Super Pathway: NA
Sub Pathway: NA
Inchikey: GPPYTCRVKHULJH

Denominator Metabolite

Structure of lignoceroylcarnitine (c24)*
Metabolite Accession: GCST90200137
Name: lignoceroylcarnitine (c24)*
Hmdb Id: HMDB0240665
Super Pathway: NA
Sub Pathway: NA
Inchikey: YDUFZFUYBBPVLJ

Associated Genomic Regions

Region: rs72795121

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.215
Position:
131638324
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
9.750
Reference Allele:
T
-log10(P):
-50.045
MAF:
0.475
Beta (Num):
0.101
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.114
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Histidine metabolism.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.8[1], 9[2], 10[3]

Ratio Explanation:

An increased ratio may indicate altered SLC22A4 function, affecting the balance between ergothioneine uptake (related to hercynine) and fatty acid metabolism, relevant in inflammation.2[1], 8[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A4-mediated transport of the antioxidant ergothioneine, derived from hercynine, could exacerbate inflammatory responses seen in psoriatic arthropathies and nasal polyps.1[1], 2[2], 11[3]

Phenotype Driver:

Gene-centric:SLC22A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data