myristoleoylcarnitine (c14:1)* to glutamine conjugate of c6h10o2 (1)*

Numerator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Denominator Metabolite

Metabolite Accession: GCST90200176
Name: glutamine conjugate of c6h10o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs4705857

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.139
Position:
131737030
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
7.884
Reference Allele:
C
-log10(P):
-33.383
MAF:
0.313
Beta (Num):
0.076
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.063
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 IRF1 P4HA2

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Xenobiotic metabolism

Ratio Explanation:

The ratio may reflect SLC22A5-mediated carnitine transport efficiency, where reduced function could alter myristoleoylcarnitine levels relative to the clearance of other metabolites.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in the SLC22A5 carnitine transporter likely alters fatty acid oxidation, an energy source critical for the development and function of high-turnover hematopoietic cells, thereby influencing neutrophil, eosinophil, and monocyte counts.4[1], 5[2], 6[3]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data