tridecenedioate (c13:1-dc)* to palmitoylcarnitine (c16)

Numerator Metabolite

Metabolite Accession: GCST90199867
Name: tridecenedioate (c13:1-dc)*
Hmdb Id: HMDB02327
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitoylcarnitine (c16)
Metabolite Accession: GCST90199666
Name: palmitoylcarnitine (c16)
Hmdb Id: HMDB0000222
Super Pathway: NA
Sub Pathway: NA
Inchikey: XOMRRQXKHMYMOC

Associated Genomic Regions

Region: rs273903

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.170
Position:
131692462
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-10.379
Reference Allele:
G
-log10(P):
-56.433
MAF:
0.294
Beta (Num):
-0.045
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.125
SE (Den):
0.017
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Dicarboxylate6[1]

Denominator Metabolite Explanation:

Fatty acid metabolism, Beta-oxidation7[1]

Ratio Explanation:

Increased tridecenedioate to palmitoylcarnitine ratio may reflect impaired fatty acid oxidation due to altered carnitine transport by SLC22A5.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function likely impairs palmitoylcarnitine transport into mitochondria for beta-oxidation7[1], 8[2], 9[3], leading to its relative decrease and a potential shift towards alternative fatty acid metabolism, reflected in the altered ratio and potentially impacting hematopoietic cell counts through downstream metabolic signaling.

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data