oleoylcarnitine (c18:1) to margarate (17:0)

Numerator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of margarate (17:0)
Metabolite Accession: GCST90200459
Name: margarate (17:0)
Hmdb Id: HMDB0002259
Super Pathway: NA
Sub Pathway: NA
Inchikey: KEMQGTRYUADPNZ

Associated Genomic Regions

Region: rs635619

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.174
Position:
131720265
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
10.355
Reference Allele:
G
-log10(P):
-56.189
MAF:
0.294
Beta (Num):
0.129
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.045
SE (Den):
0.017
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, carnitine shuttle.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid metabolism.7[1], 8[2]

Ratio Explanation:

The ratio contrasts carnitine-dependent long-chain fatty acid transport via SLC22A5 (oleoylcarnitine) against an odd-chain fatty acid (margarate), potentially indicating carnitine shuttle efficiency.1[1], 5[2], 8[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in SLC22A5 likely alters carnitine transport, affecting oleoylcarnitine formation and energy metabolism in hematopoietic cells, which plausibly influences circulating counts of neutrophils, platelets, and other white blood cells.9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data