cis-3,4-methyleneheptanoylcarnitine to oleoylcarnitine (c18:1)

Numerator Metabolite

Metabolite Accession: GCST90200266
Name: cis-3,4-methyleneheptanoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs2073644

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.189
Position:
131723289
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
-9.753
Reference Allele:
A
-log10(P):
-50.070
MAF:
0.448
Beta (Num):
-0.069
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.119
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism (acylcarnitine)

Denominator Metabolite Explanation:

Fatty acid metabolism (long-chain acylcarnitine)

Ratio Explanation:

The ratio may reflect competitive transport or altered fatty acid beta-oxidation, influenced by SLC22A4's role in carnitine transport.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A4 function likely impacts carnitine-dependent fatty acid transport, affecting energy homeostasis and immune cell function, which could connect to hematological traits and autoimmune hypothyroidism. The link to skin neoplasms may be through altered cellular metabolism or inflammation, but this is more speculative.

Phenotype Driver:

Gene-centric:SLC22A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data