hexadecadienoate (16:2n6) to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Structure of hexadecadienoate (16:2n6)
Metabolite Accession: GCST90200104
Name: hexadecadienoate (16:2n6)
Hmdb Id: HMDB0000477
Super Pathway: NA
Sub Pathway: NA
Inchikey: WPJGPAAPSBVXNU

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs274572

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.135
Position:
131710917
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-9.751
Reference Allele:
T
-log10(P):
-50.057
MAF:
0.294
Beta (Num):
-0.044
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.091
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/metabolism

Denominator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation

Ratio Explanation:

A lower ratio may indicate reduced carnitine transport by SLC22A5, leading to decreased palmitoylcarnitine synthesis and a relative increase in hexadecadienoate due to impaired fatty acid oxidation.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can impair fatty acid oxidation, potentially altering cellular energy and lipid signaling, which may influence hematopoietic cell counts like monocytes and platelets, though the direct mechanism is not fully established.4[1]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data