docosapentaenoate n3 DPA; 22:5n3 to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.155
Position:
102075479
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
9.271
Reference Allele:
G
-log10(P):
-45.437
MAF:
0.176
Beta (Num):
0.024
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.130
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs274556

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.150
Position:
131722075
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-10.759
Reference Allele:
A
-log10(P):
-60.492
MAF:
0.294
Beta (Num):
-0.058
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.092
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis, specialized pro-resolving mediator pathways.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.1[1], 7[2]

Ratio Explanation:

The ratio reflects a balance between omega-3 fatty acid metabolism and carnitine-dependent fatty acid transport, influenced by the SLC22A5 carnitine transporter.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function impairs carnitine transport, disrupting fatty acid oxidation and cellular energy balance.2[1], 3[2] This metabolic dysregulation is linked to an increased risk of cardiomyopathy, hypercholesterolemia, and coronary atherosclerosis, all of which rely on proper cardiac energy and lipid metabolism.8[3], 9[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data