palmitoleoylcarnitine (c16:1)* to 3-hydroxymyristate

Numerator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Denominator Metabolite

Structure of 3-hydroxymyristate
Metabolite Accession: GCST90199674
Name: 3-hydroxymyristate
Hmdb Id: HMDB0061656,HMDB0010731
Super Pathway: NA
Sub Pathway: NA
Inchikey: ATRNZOYKSNPPBF

Associated Genomic Regions

Region: rs2999545

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
0.121
Position:
151904146
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
9.396
Reference Allele:
T
-log10(P):
-46.617
MAF:
0.388
Beta (Num):
0.055
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.067
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

Region: rs635619

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
5
Beta (Ratio):
0.119
Position:
131720265
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
8.589
Reference Allele:
G
-log10(P):
-39.279
MAF:
0.294
Beta (Num):
0.092
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.027
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid transport, mitochondrial beta-oxidation.3[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, Lipid A formation.4[1], 5[2]

Ratio Explanation:

The ratio likely reflects the efficiency of carnitine-dependent fatty acid import for oxidation versus the synthesis or presence of a bacterial-related fatty acid.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in SLC22A5 can alter fatty acid oxidation, impacting energy homeostasis in hematopoietic cells and leading to the observed changes in blood cell counts.6[1], 7[2]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data