palmitoleoylcarnitine (c16:1)* to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs2631371

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.150
Position:
131703691
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
9.463
Reference Allele:
G
-log10(P):
-47.260
MAF:
0.294
Beta (Num):
0.091
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.059
SE (Den):
0.017
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects carnitine-dependent fatty acid transport and polyunsaturated fatty acid metabolism; its alteration may indicate shifts in cellular energy substrate utilization.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can impair carnitine uptake, affecting fatty acid oxidation and potentially influencing hematopoietic cell differentiation and function, leading to observed changes in blood cell counts.1[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data