arachidonate (20:4n6) to dihomo-linoleoylcarnitine (c20:2)*

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Metabolite Accession: GCST90200144
Name: dihomo-linoleoylcarnitine (c20:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs166635

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.232
Position:
131684042
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
-11.474
Reference Allele:
A
-log10(P):
-68.505
MAF:
0.294
Beta (Num):
-0.064
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.168
SE (Den):
0.017
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 P4HA2 C5orf56 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism, Eicosanoid synthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid transport, beta-oxidation.

Ratio Explanation:

The ratio may reflect a balance between arachidonate availability and carnitine-dependent fatty acid transport, potentially modulated by SLC22A5 transporter activity affecting dihomo-linoleoylcarnitine.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A5 function may disrupt carnitine homeostasis, affecting fatty acid metabolism. This impacts the arachidonate/dihomo-linoleoylcarnitine ratio, influencing inflammatory processes and hematopoietic cell proliferation, thus affecting blood cell counts.7[1]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data