adrenate (22:4n6) to myristoylcarnitine (c14)

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of myristoylcarnitine (c14)
Metabolite Accession: GCST90199730
Name: myristoylcarnitine (c14)
Hmdb Id: HMDB000506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PSHXNVGSVNEJBD

Associated Genomic Regions

Region: rs270614

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.174
Position:
131640813
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
-10.182
Reference Allele:
A
-log10(P):
-54.388
MAF:
0.292
Beta (Num):
-0.056
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.117
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/elongation.6[1], 7[2], 8[3], 9[4]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.10[1], 11[2], 12[3], 13[4]

Ratio Explanation:

Altered SLC22A5 function likely impairs myristoylcarnitine transport for beta-oxidation, while adrenate synthesis continues, leading to an increased ratio of adrenate to myristoylcarnitine.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SLC22A5/SLC22A4 function likely impairs carnitine-dependent fatty acid transport into mitochondria for beta-oxidation, affecting energy metabolism. This disruption in fatty acid homeostasis could plausibly influence hematopoietic cell counts, as reflected in the associated phenotypes like neutrophil and platelet counts, by altering the availability of energy or signaling molecules for cell differentiation and proliferation.

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data