palmitoleoylcarnitine (c16:1)* to stearidonate (18:4n3)

Numerator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs388891

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.134
Position:
131700794
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
8.450
Reference Allele:
G
-log10(P):
-38.073
MAF:
0.295
Beta (Num):
0.092
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.042
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Carnitine shuttle

Denominator Metabolite Explanation:

Omega-3 fatty acid metabolism

Ratio Explanation:

The ratio reflects the balance between fatty acid transport for beta-oxidation and polyunsaturated fatty acid metabolism. Altered SLC22A5 function may impact this balance.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A5 carnitine transport function likely affects acylcarnitine levels, including palmitoleoylcarnitine, and may systemically influence lipid metabolism and hematopoietic cell function, given the association of SLC22A5 with hematopoiesis and the observed links between carnitine and hematopoietic stem cells.4[1], 5[2], 6[3], 7[4], 8[5], 9[6]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data