docosapentaenoate n3 DPA; 22:5n3 to laurylcarnitine

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of laurylcarnitine (c12)
Metabolite Accession: GCST90199750
Name: laurylcarnitine (c12)
Hmdb Id: HMDB000225
Super Pathway: NA
Sub Pathway: NA
Inchikey: FUJLYHJROOYKRA

Associated Genomic Regions

Region: rs3843503

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.116
Position:
131466629
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
7.528
Reference Allele:
T
-log10(P):
-30.596
MAF:
0.453
Beta (Num):
0.056
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.059
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
CSF2 P4HA2 IL3 ACSL6 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Eicosanoid biosynthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.2[1], 7[2]

Ratio Explanation:

This ratio indicates the balance between available long-chain omega-3 fatty acids (DPA) and the capacity of the carnitine-dependent transport system for mitochondrial oxidation.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A5 function likely impairs carnitine-dependent fatty acid oxidation. This dysregulation of lipid metabolism and energy production may contribute to inflammatory conditions like psoriatic arthropathy and hypertension, and affect hematopoietic cell counts, linking to the observed phenotypes.8[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data