myristoleate (14:1n5) to myristoylcarnitine (c14)

Numerator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Denominator Metabolite

Structure of myristoylcarnitine (c14)
Metabolite Accession: GCST90199730
Name: myristoylcarnitine (c14)
Hmdb Id: HMDB000506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PSHXNVGSVNEJBD

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.143
Position:
102075479
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-8.273
Reference Allele:
G
-log10(P):
-36.578
MAF:
0.176
Beta (Num):
-0.097
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.046
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs270615

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.147
Position:
131641573
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
-10.067
Reference Allele:
C
-log10(P):
-53.213
MAF:
0.292
Beta (Num):
-0.030
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.117
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, fatty acid desaturation.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid oxidation, carnitine shuttle.7[1], 8[2]

Ratio Explanation:

This ratio reflects the balance between myristoleate availability and its mitochondrial uptake for oxidation, which depends on carnitine transported by SLC22A5.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired SLC22A5 function can disrupt carnitine-dependent fatty acid oxidation, altering lipid metabolism. This disruption is a known risk factor for cardiovascular phenotypes like atherosclerosis and myocardial infarction, which are associated with this ratio.9[1], 3[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data