dodecadienoate (12:2)* to acetylcarnitine (c2)

Numerator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Associated Genomic Regions

Region: rs272849

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
5
Beta (Ratio):
-0.152
Position:
131690241
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-9.948
Reference Allele:
G
-log10(P):
-52.018
MAF:
0.373
Beta (Num):
-0.040
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.112
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/oxidation.6[1], 7[2], 8[3], 9[4], 10[5]

Denominator Metabolite Explanation:

Fatty acid, amino acid, and carbohydrate metabolism.11[1], 12[2], 13[3], 14[4]

Ratio Explanation:

The ratio reflects carnitine-dependent transport of fatty acids for oxidation relative to acetyl-CoA buffering and export, processes modulated by SLC22A5 carnitine uptake.1[1], 11[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function likely decreases intracellular carnitine, impairing fatty acid oxidation and acetyl-CoA buffering. This can alter energy metabolism and inflammatory responses, potentially influencing neutrophil, eosinophil, monocyte, lymphocyte, and platelet counts, as well as uric acid and bilirubin levels, which are linked to inflammatory and metabolic states.

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data