myristoleate (14:1n5) to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs388891

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.157
Position:
131700794
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
-9.705
Reference Allele:
G
-log10(P):
-49.604
MAF:
0.294
Beta (Num):
-0.027
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.130
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.7[1], 8[2], 9[3], 10[4]

Ratio Explanation:

An elevated ratio suggests decreased fatty acid oxidation, as SLC22A5 impairment reduces carnitine uptake, lowering oleoylcarnitine formation and potentially increasing fatty acid precursors like myristoleate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Impaired SLC22A5 function leads to reduced carnitine transport and consequently altered fatty acid metabolism.1[1], 2[2], 3[3] This systemic carnitine deficiency can affect hematological parameters, including white and red blood cell counts, which aligns with the observed phenotypes.11[4], 12[5], 13[6], 14[7]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data