tetradecanedioate (c14-dc) to myristoylcarnitine (c14)

Numerator Metabolite

Structure of tetradecanedioate (c14-dc)
Metabolite Accession: GCST90199806
Name: tetradecanedioate (c14-dc)
Hmdb Id: HMDB0000872
Super Pathway: NA
Sub Pathway: NA
Inchikey: HQHCYKULIHKCEB

Denominator Metabolite

Structure of myristoylcarnitine (c14)
Metabolite Accession: GCST90199730
Name: myristoylcarnitine (c14)
Hmdb Id: HMDB000506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PSHXNVGSVNEJBD

Associated Genomic Regions

Region: rs273903

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.153
Position:
131692462
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-10.242
Reference Allele:
G
-log10(P):
-55.008
MAF:
0.294
Beta (Num):
-0.037
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.116
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.6[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.7[1], 8[2]

Ratio Explanation:

An increased ratio of tetradecanedioate to myristoylcarnitine suggests impaired carnitine uptake by SLC22A5, shunting fatty acids from beta-oxidation to omega-oxidation.1[1], 2[2], 6[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function and the resultant impaired fatty acid metabolism are linked to carnitine deficiency, which can provoke hypertension.9[1], 10[2], 11[3] This systemic metabolic stress may underlie the associations with hypertension and altered blood cell counts.

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data