arachidonate (20:4n6) to Hexanoylcarnitine

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of hexanoylcarnitine (c6)
Metabolite Accession: GCST90199668
Name: hexanoylcarnitine (c6)
Hmdb Id: HMDB0000756
Super Pathway: NA
Sub Pathway: NA
Inchikey: VVPRQWTYSNDTEA

Associated Genomic Regions

Region: rs149218

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.152
Position:
131669690
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
-9.114
Reference Allele:
T
-log10(P):
-43.982
MAF:
0.373
Beta (Num):
-0.059
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.093
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 P4HA2 PDLIM4 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Eicosanoid/prostaglandin synthesis4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation6[1], 7[2]

Ratio Explanation:

This ratio may represent a balance between fatty acid oxidation, which requires carnitine-dependent transport, and arachidonate metabolism, a key inflammatory pathway.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Variants in SLC22A5, a carnitine transporter, alter fatty acid metabolism and have been linked to changes in neutrophil and platelet counts and are associated with inflammatory conditions, potentially explaining the link to hematopoietic phenotypes and uric acid levels.8[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data