3-hydroxylaurate to acetylcarnitine (c2)

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Associated Genomic Regions

Region: rs419291

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.134
Position:
131633355
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
-9.638
Reference Allele:
C
-log10(P):
-48.947
MAF:
0.372
Beta (Num):
-0.022
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.112
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.6[1], 7[2]

Ratio Explanation:

An elevated ratio of 3-hydroxylaurate to acetylcarnitine could indicate impaired carnitine-dependent fatty acid oxidation, potentially due to reduced SLC22A5 transporter function.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function may impair carnitine uptake, affecting fatty acid oxidation and leading to altered levels of inflammatory and immune cell-related metabolites, which could influence hematological traits like neutrophil and white blood cell counts.8[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data