(s)-3-hydroxybutyrylcarnitine to glutamine conjugate of c6h10o2 (1)*

Numerator Metabolite

Structure of (s)-3-hydroxybutyrylcarnitine
Metabolite Accession: GCST90200088
Name: (s)-3-hydroxybutyrylcarnitine
Hmdb Id: HMDB0013127
Super Pathway: NA
Sub Pathway: NA
Inchikey: UEFRDQSMQXDWTO

Denominator Metabolite

Metabolite Accession: GCST90200176
Name: glutamine conjugate of c6h10o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs2933243

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.108
Position:
56860577
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
7.766
Reference Allele:
G
-log10(P):
-32.447
MAF:
0.195
Beta (Num):
0.015
Novel Locus:
Yes ✔️
SE (Num):
0.018
Beta (Den):
-0.093
SE (Den):
0.019
No CNV overlap
rQTL cluster:
51
Reaction Distance:
NA
Closest Genes:
MIP SPRYD4 GLS2 TIMELESS RBMS2

Region: rs2631372

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.118
Position:
131703578
SE (Ratio):
0.012
Effect Allele:
C
Z-score (Ratio):
9.835
Reference Allele:
G
-log10(P):
-50.887
MAF:
0.294
Beta (Num):
0.059
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.059
SE (Den):
0.017
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, ketone body metabolism.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Glutamine conjugation, xenobiotic detoxification.8[1]

Ratio Explanation:

The ratio may reflect the balance between fatty acid oxidation for energy and glutamine-dependent detoxification, potentially influenced by carnitine transport (SLC22A5) and glutamine metabolism (GLS2).

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A5 and GLS2 function can disrupt the balance between fatty acid oxidation and glutamine metabolism, impacting energy availability and detoxification, which may contribute to variations in immune cell counts (monocytes, lymphocytes, neutrophils) and inflammatory markers (CRP).9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data