tetradecadienoate (14:2)* to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs6685187

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.163
Position:
151858888
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-11.592
Reference Allele:
G
-log10(P):
-69.870
MAF:
0.398
Beta (Num):
-0.124
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.039
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC LINGO4

Region: rs388891

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.153
Position:
131700794
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
-10.166
Reference Allele:
G
-log10(P):
-54.223
MAF:
0.295
Beta (Num):
-0.023
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.130
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/oxidation.4[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.5[1], 6[2]

Ratio Explanation:

Reduced SLC22A5 function impairs carnitine transport, decreasing oleoylcarnitine synthesis and potentially altering fatty acid pools, thus increasing the ratio of tetradecadienoate to oleoylcarnitine.1[1], 2[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A5 function impacts carnitine-dependent fatty acid metabolism, reflected in the metabolite ratio. This systemic effect on energy metabolism likely influences hematopoietic cell production and function, leading to observed changes in neutrophil, platelet, and other blood cell counts.7[1], 8[2], 9[3]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data