dihomo-linolenate (20:3n3 or n6) to myristoleoylcarnitine (c14:1)*

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Associated Genomic Regions

Region: rs7943728

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.184
Position:
61547068
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
9.441
Reference Allele:
G
-log10(P):
-47.048
MAF:
0.179
Beta (Num):
0.144
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.040
SE (Den):
0.020
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

Region: rs272880

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
5
Beta (Ratio):
-0.127
Position:
131670178
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
-7.775
Reference Allele:
T
-log10(P):
-32.518
MAF:
0.294
Beta (Num):
-0.053
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.074
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 P4HA2 PDLIM4 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation/Carnitine shuttle.6[1], 7[2]

Ratio Explanation:

This ratio reflects the balance between polyunsaturated fatty acid (PUFA) synthesis, influenced by FADS1, and fatty acid transport for mitochondrial oxidation via the carnitine shuttle.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters polyunsaturated fatty acid levels, impacting inflammatory mediator production and skin barrier function.8[1], 9[2] This dysregulation is linked to inflammatory phenotypes like seborrhoeic dermatitis and sinusitis, which are associated with the genetic loci.10[3], 11[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data