docosapentaenoate n3 DPA; 22:5n3 to acetylcarnitine (c2)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Associated Genomic Regions

Region: rs272849

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.171
Position:
131690241
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-11.368
Reference Allele:
G
-log10(P):
-67.277
MAF:
0.373
Beta (Num):
-0.059
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.112
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/metabolism8[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle9[1], 10[2], 11[3]

Ratio Explanation:

The ratio may reflect a balance between fatty acid availability (DPA) and carnitine-dependent fatty acid oxidation, influenced by SLC22A4/A5 transporter activity.12[1], 1[2], 13[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the SLC22A4 transporter, known to be involved in inflammatory pathways, likely alters cellular metabolism, which is reflected in the DPA/acetylcarnitine ratio and contributes to downstream alterations in immune cell counts like monocytes and lymphocytes.4[1], 5[2], 14[3], 15[4], 16[5], 17[6], 18[7]

Phenotype Driver:

Gene-centric:SLC22A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data