arachidonate (20:4n6) to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs272855

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.194
Position:
131687175
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
-11.355
Reference Allele:
T
-log10(P):
-67.134
MAF:
0.294
Beta (Num):
-0.064
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.130
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 P4HA2 C5orf56 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Eicosanoid synthesis, prostaglandin/thromboxane/leukotriene formation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.2[1], 7[2], 8[3]

Ratio Explanation:

The ratio may reflect carnitine-dependent fatty acid transport efficiency, where altered SLC22A5 function could impact levels of both fatty acids and their carnitine conjugates.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can impair carnitine uptake, affecting fatty acid oxidation and potentially leading to the accumulation of certain fatty acids and their carnitine esters, which may influence hematological traits like monocyte and platelet counts through altered inflammatory signaling.2[1], 7[2], 4[3], 9[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data